Weight loss, glycolipid profile changes in type 2 diabetes patients after esophagectomy: a propensity score matching analysis.

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a common co-morbidity in patients who receive esophagectomy and has unfavorable effects on glucose and lipid metabolism in patients. This study examines how weight and glycolipid metabolism change in patients with T2DM following esophagectomy. METHODS: This retrospective, one-center, observational analysis with a propensity score matching analysis (PSM) included 114 patients who underwent esophageal surgery in the Department of Cardiothoracic Surgery, the 900th Hospital of Joint Logistic Support Force from 2017 to 2020, which were separated into T2DM group and Non-T2DM group. Weight, body mass index (BMI), fasting plasma glucose (FPG), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were measured and analyzed before and after the operation. RESULTS: Two groups showed similar reductions in weight and BMI after surgery. In the T2DM group, weight decreased from 63.10(10.31) before surgery to 55.10(11.60) kg at 6 months (P < 0.001) with BMI decreasing from 22.67 (2.90) to 19.77 (3.48); While in the Non-T2DM group, weight decreased from 61.42 (8.46) to 53.19 (9.26) kg at 6 months after surgery with BMI decline from 22.49 (2.77) before operation to 19.45 (3.08) at 6 months after surgery. Fasting plasma glucose levels showed a significant decrease (P = 0.035) in the T2DM group at a six-month point of 7.00 (2.21) mmol/L compared to preoperative levels of 7.67 (2.32) mmol/L. HDL levels increased significantly in the Non-T2DM group at six months postoperatively at 1.52 (0.05) with P < 0.001 compared to preoperative levels of 1.22(0.04) mmol/L. TG, LDL, and TC levels decreased significantly in both groups from the preoperative to the 6-month point. CONCLUSIONS: Esophagectomy induces weight loss in T2DM and Non-T2DM groups, improves long-term glucose metabolism in the T2DM group, and enhances lipid metabolism in both groups. Further research is needed to understand their mechanisms.

Effect of oesophagectomy on lipid profiles in patients with oesophageal cancer combined with hyperlipidaemia: a retrospective study.

BACKGROUND: Surgery is widely regarded as a pivotal therapeutic approach for treating oesophageal cancer, and clinical observations have revealed that many oesophageal cancer patients also present with concomitant hyperlipidaemia. It is surprising that few studies have been performed to determine how blood lipid levels are affected by oesophageal cancer resection. This research was designed to assess the influence of oesophageal cancer resection on lipid profiles among individuals diagnosed with both oesophageal cancer and hyperlipidaemia. METHODS: A retrospective analysis was carried out on 110 patients with hyperlipidaemia and oesophageal cancer who had undergone oesophagectomy at the 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army. Preoperative and postoperative serological data were collected at seven-, thirty-, sixty-day-, and one-year-long intervals. Changes in lipid levels were compared, the remission of various types of hyperlipidaemia was statistically assessed, and Pearson correlation was used to analyse the association between lipid changes and preoperative body weight. The research sought to assess the reduction in body weight and the proportion of body weight lost one year following surgery. RESULTS: Noteworthy decreases were observed in total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) levels, with TC decreasing from 6.20 mmol/L to 5.20 mmol/L, TG decreasing from 1.40 mmol/L to 1.20 mmol/L, and LDL decreasing from 4.50 mmol/L to 3.30 mmol/L. Conversely, there was a notable increase in high-density lipoprotein (HDL) levels, which increased from 1.20 mmol/L to 1.40 mmol/L (P < 0.05) compared to the preoperative levels. Notably, the remission rates for mixed hyperlipidaemia (60.9%) and high cholesterol (60.0%) were considerably greater than those for high triglycerides (16.2%). Alterations in TC at one year postoperatively correlated with preoperative weight and weight loss (r = 0.315, -0.216); changes in TG correlated with preoperative weight, percentage of total weight loss (TWL%), and weight reduction (r = -0.295, -0.246, 0.320); and changes in LDL correlated with preoperative weight, TWL%, and weight loss (r = 0.251, 0.186, and -0.207). Changes in non-high-density lipoprotein(non-HDL) were linked to preoperative weight (r = 0.300), and changes in TG/HDL were correlated with preoperative weight and TWL% (r = -0.424, -0.251). CONCLUSIONS: Oesophagectomy significantly improved lipid profiles in oesophageal cancer patients, potentially leading to a reduction in overall cardiovascular risk.

Universal Strategy of Efficient Intracellular Macromolecule Directional Delivery Using Photothermal Pump Patch.

The development of a highly efficient, nondestructive, and in vitro/vivo-applicable universal delivery strategy of therapeutic macromolecules into desired cells and tissues is very challenging. Photothermal methods have advantages in intracellular delivery, particularly in in vivo manipulation. However, the inability of directional transmission of exogenous molecules limits their delivery efficiency. Here, a photothermal pump (PTP) patch with numerous "exogenous molecular reservoirs" is reported. Under a laser, the cell membrane ruptures, while "exogenous molecular reservoirs" shrink, resulting in a directional exogenous molecule delivery into cells for a high-efficient intracellular delivery. The PTP patches are considered a universal structure for a highly efficient, nondestructive, and in-vitro/vivo-applicable intracellular macromolecule delivery. Under in vivo transdermal intracellular delivery conditions, the target genes are efficiently and noninvasively delivered into epidermal and dermal cells through the PTP patch and exosomes produced by the epidermal cells, respectively. The PTP patch provides a new strategy for a high-efficiency, nondestructive, and in-vitro/vivo-applicable macromolecule delivery.

Diclofenac degradation by activating peroxydisulfate via well-dispersed GO/Cu2O nano-composite.

Owing to high treatment efficiency under neutral condition and no extra energy required, copper-mediated activation of persulfate (PS) has been widely used for the degradation of refractory organic pollutants in water. The dispersion stability of copper nanoparticle in water, however, remains a great challenge. Meanwhile, chemical oxidative modification of graphene oxide (GO) can improve the dispersion stability of GO in water. In this paper, cuprous oxide (Cu2O) was deposited on the surface of GO. GO/Cu2O nano-composites with different mass ratios, i.e., m(GO):m(Cu2O) of 1:2, 1:5, 1:10, and 1:25, were prepared. When m(GO):m(Cu2O) was 1:2, the amount of GO/Cu2O nano-composite was 1.00 g/L and CPDS:CDCF was 15:1, and the catalytic degradation rate of diclofenac (DCF) was up to 90%. Corresponding physicochemical properties of the resulting samples were comprehensively characterized by using SEM, TEM, XRD, Raman, FT-IR, and XPS. DCF degradation by activating peroxydisulfate (PDS) via GO/Cu2O nano-composite was also investigated in detail. It is found that the synergistic effect, namely GO adsorption and multivalent copper ion electron transfer, makes GO/Cu2O nano-composite reveal higher reactivity. Moreover, GO/Cu2O nano-composite possesses good stability in consecutive cycling test. EPR analyses shows that ·OH and SO4·- radicals are involved in DCF degradation. It is indicated that the DCF degradation process contain hydroxylation and the cleavage of C-N bond, which is explored by GC-MS. In our research, well-dispersed GO/Cu2O nano-composite with high capacity and good cycling stability was fabricated successfully. Compared with pure Cu2O nanoparticle, GO/Cu2O nano-composite exhibits the better performance for DCF removal. A novel well-dispersed cuprous oxide (Cu2O) deposited on surface of GO was fabricated with high catalytic performance. Its heterogeneous activation of peroxydisulfate (PDS) for diclofenac (DCF) degradation was investigated. GO/Cu2O nano-composite was proved high capacity and good cycling stability. Meanwhile, the possible DCF degradation pathway was explored. Compared with pure Cu2O nanoparticle, GO/Cu2O nano-composite exhibits better performance for DCF removal.

Bi5O7I/g-C3N4 Heterostructures With Enhanced Visible-Light Photocatalytic Performance for Degradation of Tetracycline Hydrochloride.

Bi5O7I/g-C3N4 p-n junctioned photocatalysts were synthesized by alcohol-heating and calcination in air. The structures, morphologies and optical properties of as-prepared samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV-Vis diffuse reflectance spectroscopy (DRS). Photocatalytic activity of the heterojunctioned composites were evaluated by degradation of Rhodamine B (RhB) and tetracycline hydrochloride (TCH) under visible light illumination. The results indicated that the composites exhibited superior efficiencies for photodegradation of RhB and TCH in comparison with pure BiOI, Bi5O7I and g-C3N4. An effective built-in electric field was formed by the interface between p-type Bi5O7I and n-type g-C3N4, which promoted the efficient separation of photoinduced electron-hole pairs. In addition, 8% Bi5O7I/g-C3N4 composite showed excellent photostability in a five-cycle photocatalytic experiment. Experiments on scavenging active intermediates revealed the roles of active species.

Diclofenac degradation based on shape-controlled cuprous oxide nanoparticles prepared by using ionic liquid.

Persulfate oxidation technology is widely used in wastewater treatment, but there are still many disadvantages, such as high energy consumption, side reaction and narrow pH applicability. Copper oxides can activate persulfate steadily with higher efficiency. In this paper, a novel preparation method of shape-controlled cuprous oxide (Cu2O) nanoparticles featured with high catalytic performance was explored. It was found that adding ionic liquid 1-butyl-3-methylimidazolium bromide ([BMIM]Br) during preparation of Cu2O can improve the degradation rate of diclofenac (DCF). Cu2O nanoparticles possess good stability in consecutive cycling tests, which was confirmed by X-ray photoelectron spectroscopy. The possible mechanism of Cu2O activating persulfate at different initial pH conditions was discussed based on electron paramagnetic resonance spin-trapping experiment. It was found that DCF was efficiently degraded in the Cu2O/peroxydisulfate (PDS) system within a broad pH range from 5 to 11. It proved via a quenching experiment that the activation process of PDS mainly occurs on the surface layer of Cu2O nanoparticles. As a result, shape-controlled Cu2O nanoparticles prepared by ionic liquid are expected to be used for in situ chemical oxidation, which is an effective oxidation processes to degrade DCF remaining in surface water and ground water.

Vascular cell responses to silicone surfaces grafted with heparin-like polymers: surface chemical composition vs. topographic patterning.

Heparin-like polymers are promising synthetic materials with biological functionalities, such as anticoagulant ability, growth factor binding to regulate cellular functions, and inflammation mediation, similar to heparin. The biocompatibility of heparin-like polymers with well-defined chemical structures has inspired many researchers to design heparin-like surfaces to explore their biological applications. The concept of the recombination of functional heparin structural units (sulfonate- and glyco-containing units) was proven to be successful in designing heparin-mimicking surfaces. However, besides surface structural units, topographic patterning is also an important contributor to the biological activity of the surfaces modified with heparin-like polymers. In this work, both surface structural units and topographic patterning were taken into account to investigate the vascular cell behaviors on the silicone surfaces. A facile method for the production of patterned bromine-containing polydimethylsiloxane surface (PDMS-Br) was developed from a one-step multicomponent thermocuring procedure and replica molding using a nanohole-arrayed silicon template. Different structural units of heparin-like polymers, i.e. homopolymer of sulfonate-containing sodium 4-vinylbenzenesulfonate (pSS), homopolymer of glyco-containing 2-(methacrylamido)glucopyranose (pMAG), and copolymers of MAG and SS (pSG), were then introduced on the flat and patterned PDMS-Br surface using visible light-induced graft polymerization. For the flat surfaces, compared with the PDMS-Br surface, pSS-grafted and pSG-grafted surfaces significantly increased cell densities of both human umbilical vein endothelial cells (HUVECs) and human umbilical vein smooth muscle cells (HUVSMCs), indicating that they are "vascular cell-friendly". In contrast, the pMAG-grafted surface showed decreased cell attachment of both HUVECs and HUVSMCs, indicating that the pMAG-grafted surface is "vascular cell-resistant". Moreover, surface topographic patterning enhanced the cell responses to the corresponding flat surfaces. That is to say, surface patterning can make the "vascular cell-friendly" surface still friendly, and the "vascular cell-resistant" surface much more resistant. The combination of surface structural units and topographic patterning shows promise in the preparation of new heparin-like surfaces with improved cell compatibility that is suitable for blood-compatible biomaterials.

Nitric Oxide-Generating Antiplatelet Polyurethane Surfaces with Multiple Additional Biofunctions via Cyclodextrin-Based Host-Guest Interactions.

A nitric oxide-generating polymeric coating was prepared by copolymerization of the hydrophilic monomer 2-hydroxyethyl methacrylate (HEMA) and the comonomer 1-adamantan-1-ylmethyl methacrylate (AdaMA) with subsequent incorporation of selenocystamine. The coating was applied to polyurethane (PU) as a substrate. In the presence of a NO donor, the PU-PHA-Se surface generated nitric oxide (NO). This surface was shown to inhibit platelet adhesion and human umbilical vein smooth muscle cell adhesion and proliferation. The poly(AdaMA) on the modified surface was designed to allow the incorporation of functional units into the PU-PHA-Se surface via host-guest interactions between the adamantane groups and cyclodextrin (CD) derivatives. In this work, two functional CD complexes containing lysine (CD-L) and sulfonate (CD-S) groups were incorporated into the PU-PHA-Se surface. CD-L conferred fibrinolytic activity, whereas CD-S promoted human umbilical vein endothelial cell proliferation. This NO-generating antiplatelet polymeric coating has potential as a platform for modifying surfaces with multiple additional biological functions via host-guest interactions, thus providing an alternative approach for the preparation of biomaterials with multifunctionality.

[Heavy metal pollution characteristics and ecological risk analysis for soil around Haining electroplating industrial park].

The pollution status and potential ecological risks of heavy metal in soils around Haining electroplating industrial park were studied. Hakanson index approach was used to assess the ecological hazards of heavy metals in soils. Results showed that average concentrations of six heavy metals (Cu, Ni, Pb, Zn, Cd and Cr) in the soils were lower than the secondary criteria of environmental quality standard for soils, indicating limited harmful effects on the plants and the environment in general. Though the average soil concentrations were low, heavy metal concentrations in six sampling points located at the side of road still exceeded the criteria, with excessive rate of 13%. Statistic analysis showed that concentrations of Cu and Cd in roadside soils were significantly higher than those in non-roadside soils, indicating that the excessive heavy metal accumulations in the soil closely related with traffic transport. The average potential ecological hazard index of soils around Haining electroplating industrial park was 46.6, suggesting a slightly ecological harm. However, the potential ecological hazard index of soils with excessive heavy metals was 220-278, suggesting the medium ecological hazards. Cd was the most seriously ecological hazard factor.

[The microscopical and HPLC identification of several" Muxiang" raw materials].

OBJECTIVE: To differentiate and identify several species of "Muxiang". METHODS: The main microscopic features and HPLC chromatograms of diagnostic components were studied. RESULTS: Distinguishable characters were found in two methods. CONCLUSION: The results provide reliable and simple reference for the authentication of raw materials of" Muxiang" species, especially the toxic species.